What is chronic kidney disease?
Chronic kidney disease is a condition where the kidneys don’t work the way they’re supposed to, causing many different health issues.
Kidneys are important for many processes in the body. The kidney’s main job is to filter blood, keeping in vital salts and minerals and removing waste in your urine (pee). The kidney also releases hormones that tell your body to control blood pressure, make new blood cells, and make your bones stronger. When kidneys don’t work properly, it can cause many health issues.
There are different types of chronic kidney disease, including APOL1-mediated kidney disease. The AMPLITUDE clinical research study is exploring an investigational study drug for APOL1-mediated kidney disease.
What is APOL1-mediated kidney disease?
APOL1-mediated kidney disease is a type of kidney disease that is caused by a substance in our body called the APOL1 protein (also known as the apolipoprotein L1). We all have the APOL1 protein; however, some people have differences in their DNA (the genetic material in our body that carries information about how our body works) that means they carry a modified type of APOL1 protein, known as a variant. This puts them at a higher risk for chronic kidney disease. How this variant of APOL1 causes kidney disease is still not known.
This variant of APOL1 is more likely to occur in people of African ancestry. African ancestry includes people who identify as African American, Black, Caribbean, Sub-Saharan African, and Latino (Cuban, Mexican, Puerto Rican or South or Central American).
If you have kidney disease, you may not know if you carry this variant of APOL1 protein. The only way to find out if you have the variant of APOL1 that puts you at risk for kidney disease is to examine your DNA, in a process called genetic testing.
Why it’s important to understand more about APOL1-mediated kidney disease
APOL1-mediated kidney disease is caused by differences in DNA, called variants. You share some of your DNA with your blood relatives. This means that APOL1-mediated kidney disease can be passed down through generations and can affect many people within the same family.
Right now, treatments for chronic kidney disease are only able to control some parts of the disease, like high blood pressure. Therefore, it is important to research treatments that could help stop kidney function from getting worse, as well as investigating the cause of chronic kidney disease.
It’s important that we start learning more about APOL1-mediated kidney disease now, so that we can potentially help people living with this disease in the future.
You can see if you meet some of the criteria to take part by completing the questionnaire here.